As the data center backlash grows, support is growing for server factories and the hundreds of jobs they're expected to bring. Last month, Pamela Griffin and two other residents of Taylor, Texas, took to the lectern at a city council meeting to object to a data center project. But later, they sat back as council members discussed a proposed tech factory. Griffin didn't speak up against that development. A similar contrast is repeating in communities across the US.

Most real-world processes occur across space and time, exhibit complex dependencies, and are observed through noisy irregular samples.

Motile nanosized particles, or "nanobots", promise more effective and less toxic targeted drug delivery because of their unique scale and precision. We consider the case in which the cancer is "diffuse", dispersed such that there are multiple distinct cancer sites. We investigate the problem of a swarm of nanobots locating these sites and treating them by dropping drug payloads at the sites. To improve the success of the treatment, the drug payloads must be allocated between sites according to their "demands"; this requires extra nanobot coordination. We present a mathematical model of the behavior of the nanobot agents and of their colloidal environment. This includes a movement model for agents based upon experimental findings from actual nanoparticles in which bots noisily ascend and descend chemical gradients. We present three algorithms: The first algorithm, called KM, is the most representative of reality, with agents simply following naturally existing chemical signals that surround each cancer site. The second algorithm, KMA, includes an additional chemical payload which amplifies the existing natural signals. The third algorithm, KMAR, includes another additional chemical payload which counteracts the other signals, instead inducing negative chemotaxis in agents such that they are repelled from sites that are already sufficiently treated. We present simulation results for all algorithms across different types of cancer arrangements. For KM, we show that the treatment is generally successful unless the natural chemical signals are weak, in which case the treatment progresses too slowly. For KMA, we demonstrate a significant improvement in treatment speed but a drop in eventual success, except for concentrated cancer patterns. For KMAR, our results show great performance across all types of cancer patterns, demonstrating robustness and adaptability.

Recent research shows how diffusion models can unconditionally generate tile-based game levels, but use of diffusion models for text-to-level generation is underexplored. There are practical considerations for creating a usable model: caption/level pairs are needed, as is a text embedding model, and a way of generating entire playable levels, rather than individual scenes. We present strategies to automatically assign descriptive captions to an existing dataset, and train diffusion models using both pretrained text encoders and simple transformer models trained from scratch. Captions are automatically assigned to generated scenes so that the degree of overlap between input and output captions can be compared. We also assess the diversity and playability of the resulting level scenes. Results are compared with an unconditional diffusion model and a generative adversarial network, as well as the text-to-level approaches Five-Dollar Model and MarioGPT. Notably, the best diffusion model uses a simple transformer model for text embedding, and takes less time to train than diffusion models employing more complex text encoders, indicating that reliance on larger language models is not necessary. We also present a GUI allowing designers to construct long levels from model-generated scenes.

Deploying motile nanosized particles, also known as ``nanobots'', in the human body promises to improve selectivity in drug delivery and reduce side effects. We consider a swarm of nanobots locating a single cancerous region and treating it by releasing an onboard payload of drugs at the site. At nanoscale, the computation, communication, sensing, and locomotion capabilities of individual agents are extremely limited, noisy, and/or nonexistent. We present a general model to formally describe the individual and collective behavior of agents in a colloidal environment, such as the bloodstream, for cancer detection and treatment by nanobots. This includes a feasible and precise model of agent locomotion, inspired by actual nanoparticles that, in the presence of an external chemical gradient, move towards areas of higher concentration by means of self-propulsion. We present two variants of our general model: The first assumes an endogenous chemical gradient that is fixed over time and centered at the targeted cancer site; the second is a more speculative and dynamic variant in which agents themselves create and amplify a chemical gradient centered at the cancer site. In both settings, agents can sense the gradient and ascend it noisily, locating the cancer site more quickly than via simple Brownian motion. For the first variant of the model, we present simulation results to show the behavior of agents under our locomotion model, as well as {analytical results} to bound the time it takes for the agents to reach the cancer site. For the second variant, simulation results highlight the collective benefit in having agents issue their own chemical signal. While arguably more speculative in its agent capability assumptions, this variant shows a significant improvement in runtime performance over the first variant, resulting from its chemical signal amplification mechanism.

This paper presents the implementation of a self-replicating finite-state machine (FSM) and a self-replicating Turing Machine (TM) using bio-inspired mechanisms. Building on previous work that introduced self-replicating structures capable of sorting, copying, and reading information, this study demonstrates the computational power of these mechanisms by explicitly constructing a functioning FSM and TM. This study demonstrates the universality of the system by emulating the UTM(5,5) of Neary and Woods.

This study presents a theoretical model for a self-replicating mechanical system inspired by biological processes within living cells and supported by computer simulations. The model decomposes self-replication into core components, each of which is executed by a single machine constructed from a set of basic block types. Key functionalities such as sorting, copying, and building, are demonstrated. The model provides valuable insights into the constraints of self-replicating systems. The discussion also addresses the spatial and timing behavior of the system, as well as its efficiency and complexity. This work provides a foundational framework for future studies on self-replicating mechanisms and their information-processing applications.

Undirected graphical models, also known as Markov networks, enjoy popularity in a variety of applications. The popular instances of these models such as Gaussian Markov Random Fields (GMRFs), Ising models, and multinomial discrete models, however do not capture the characteristics of data in many settings. We introduce a new class of graphical models based on generalized linear models (GLMs) by assuming that node-wise conditional distributions arise from exponential families. Our models allow one to estimate multivariate Markov networks given any univariate exponential distribution, such as Poisson, negative binomial, and exponential, by fitting penalized GLMs to select the neighborhood for each node. A major contribution of this paper is the rigorous statistical analysis showing that with high probability, the neighborhood of our graphical models can be recovered exactly. We also provide examples of non-Gaussian high-throughput genomic networks learned via our GLM graphical models.

In 2023, people who want to reside in Georgetown, Texas, may have the opportunity to live in a large, 3D-printed neighborhood. Homebuyers interested in relocating to Georgetown, Texas, may have the opportunity to live in a large, 3D-printed neighborhood. ICON, a construction tech company, along with Lennar, a home construction company and Bjarke Ingels Group (BIG), an architecture company, are teaming up to develop Wolf Ranch -- a 100-home, 3D-printed community. "Wolf Ranch marks the largest community of its kind in development in the world and in partnership with one of the largest home builders in the country, Lennar," Dmitri Julius, chief of special projects at ICON, told Fox News Digital. The partnership between Austin-based ICON and Lennar "offers a promising path toward an alternate method of delivering technology-driven homes that meet rising demand in desirable communities," Julius added.